Samiksha Jaiswal (Editor)

TRNAIle lysidine synthase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
6.3.4.19

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
635304-92-6

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

TRNAIle-lysidine synthase (EC 6.3.4.19, TilS, mesJ (gene), yacA (gene), isoleucine-specific transfer ribonucleate lysidine synthetase, tRNAIle-lysidine synthetase) is an enzyme with systematic name L-lysine:(tRNAIle2)-cytidine34 ligase (AMP-forming). This enzyme catalyses the following chemical reaction

[tRNAIle2]-cytidine34 + L-lysine + ATP ⇌ [tRNAIle2]-lysidine34 + AMP + diphosphate + H2O

The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNAIle at the oxo group in position 2 of cytidine34.

References

TRNAIle-lysidine synthase Wikipedia
(Text) CC BY-SA