Harman Patil (Editor)

TRNAHis guanylyltransferase

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EC number
  
2.7.7.79

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

MetaCyc
  
metabolic pathway

TRNAHis guanylyltransferase (EC 2.7.7.79, histidine tRNA guanylyltransferase, Thg1p, Thg1) is an enzyme with systematic name p-tRNAHis:GTP guanylyltransferase (ATP-hydrolysing). This enzyme catalyses the following chemical reaction

p-tRNAHis + ATP + GTP ⇌ pppGp-tRNAHis + AMP + diphosphate (overall reaction) (1a) p-tRNAHis + ATP ⇌ App-tRNAHis + diphosphate (1b) App-tRNAHis + GTP ⇌ pppGp-tRNAHis + AMP

The enzyme requires a divalent cation for activity.

References

TRNAHis guanylyltransferase Wikipedia
(Text) CC BY-SA