TRNAHis guanylyltransferase

Updated on Oct 01, 2024

Edit

Comment

EC number 2.7.7.79 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

TRNAHis guanylyltransferase (EC 2.7.7.79, histidine tRNA guanylyltransferase, Thg1p, Thg1) is an enzyme with systematic name p-tRNAHis:GTP guanylyltransferase (ATP-hydrolysing). This enzyme catalyses the following chemical reaction

p-tRNAHis + ATP + GTP ⇌ pppGp-tRNAHis + AMP + diphosphate (overall reaction) (1a) p-tRNAHis + ATP ⇌ App-tRNAHis + diphosphate (1b) App-tRNAHis + GTP ⇌ pppGp-tRNAHis + AMP

The enzyme requires a divalent cation for activity.

References

TRNAHis guanylyltransferase Wikipedia

(Text) CC BY-SA