TRNA (guanine37 N1) methyltransferase

TRNA (guanine³⁷-N¹)-methyltransferase (EC 2.1.1.228, TrmD, tRNA (m1G37) methyltransferase, transfer RNA (m1G37) methyltransferase, Trm5p, TRMT5, tRNA-(N1G37) methyltransferase, MJ0883 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine³⁷-N¹)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine³⁷ in tRNA ⇌ S-adenosyl-L-homocysteine + N¹-methylguanine³⁷ in tRNA

This enzyme is important for the maintenance of the correct reading frame during translation.