TRNA (guanine26 N2) dimethyltransferase

Updated on Dec 31, 2024

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EC number 2.1.1.216 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

TRNA (guanine²⁶-N²)-dimethyltransferase (EC 2.1.1.216, Trm1p, TRM1, tRNA (m22G26)dimethyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine²⁶-N²)-dimethyltransferase. This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + guanine²⁶ in tRNA ⇌ 2 S-adenosyl-L-homocysteine + N²-dimethylguanine26 in tRNA

The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions.

References

TRNA (guanine26-N2)-dimethyltransferase Wikipedia

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