TRNA (cytosine38 C5) methyltransferase

Updated on Dec 31, 2024

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EC number 2.1.1.204 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

TRNA (cytosine38-C5)-methyltransferase (EC 2.1.1.204, hDNMT2 (gene), DNMT2 (gene), TRDMT1 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine³⁸ in tRNA ⇌ S-adenosyl-L-homocysteine + 5-methylcytosine³⁸ in tRNA

The eukaryotic enzyme catalyses methylation of cytosine³⁸ in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC).

References

TRNA (cytosine38-C5)-methyltransferase Wikipedia

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