TRNA (cytidine56 2' O) methyltransferase

tRNA (cytidine56-2'-O)-methyltransferase (EC 2.1.1.206, aTrm⁵⁶, tRNA ribose 2'-O-methyltransferase aTrm⁵⁶, PAB1040 (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine56-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine⁵⁶ in tRNA ⇌ S-adenosyl-L-homocysteine + 2'-O-methylcytidine⁵⁶ in tRNA

The archaeal enzyme specifically catalyses the S-adenosyl-L-methionine dependent 2'-O-ribose methylation of cytidine at position 56 in tRNA transcripts.