TRNA (cytosine34 C5) methyltransferase

Updated on Oct 12, 2024

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EC number 2.1.1.203 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

TRNA (cytosine34-C5)-methyltransferase (EC 2.1.1.203, hTrm4 Mtase, hTrm4 methyltransferase, hTrm4 (gene), tRNA:m5C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytosine³⁴ in tRNA precursor ⇌ S-adenosyl-L-homocysteine + 5-methylcytosine³⁴ in tRNA precursor

The human enzyme is specific for C⁵-methylation of cytosine³⁴ in tRNA precursors.

References

TRNA (cytosine34-C5)-methyltransferase Wikipedia

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