TRNA (adenine9 N1) methyltransferase

Updated on Jan 27, 2024

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EC number 2.1.1.218 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

TRNA (adenine⁹-N¹)-methyltransferase (EC 2.1.1.218, Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, TK0422p (gene), tRNA m1A9-methyltransferase, tRNA m1A9 Mtase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine⁹-N¹)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine⁹ in tRNA ⇌ S-adenosyl-L-homocysteine + N¹-methyladenine⁹ in tRNA

The enzyme from Sulfolobus acidocaldarius specifically methylates adenine⁹ in tRNA.

References

TRNA (adenine9-N1)-methyltransferase Wikipedia

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