Species Human Entrez 51669 | Human Mouse Ensembl ENSG00000133872 | |
Aliases SARAF, FOAP-7, TMEM66, XTP3, HSPC035, store-operated calcium entry associated regulatory factor External IDs MGI: 1915137 HomoloGene: 9398 GeneCards: SARAF | ||
SARAF is a protein that in humans is encoded by the SARAF gene, formerly known as TMEM66 (transmembrane protein 66).
Function
SARAF (TMEM66) is a negative regulator of the store-operated calcium channel (SOCE) into cells. SARAF is an endoplasmic reticulum (ER) membrane resident protein that associates with STIM1, to facilitate the inactivation of SOCE. SARAF plays a key role in shaping cytoplasmic calcium signals and determining the content of the major intracellular Ca2+ stores in the cell. By doing so it is likely to be important in protecting cells from calcium overfilling.
References
TMEM66 Wikipedia(Text) CC BY-SA