Entrez 9524 | Ensembl ENSG00000099797 | |
Aliases TECR, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase External IDs MGI: 1915408 HomoloGene: 36231 GeneCards: TECR | ||
Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.
Clinical relevance
Mutations in this gene have been shown to cause non-syndromic mental retardation.
References
TECR Wikipedia(Text) CC BY-SA