Supriya Ghosh (Editor)

TECR

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Covid-19
Species  Human
Entrez  9524
Human  Mouse
Ensembl  ENSG00000099797
Aliases  TECR, GPSN2, MRT14, SC2, TER, trans-2,3-enoyl-CoA reductase
External IDs  MGI: 1915408 HomoloGene: 36231 GeneCards: TECR

Trans-2,3-enoyl-CoA reductase is an enzyme that in humans is encoded by the TECR gene.

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.

Clinical relevance

Mutations in this gene have been shown to cause non-syndromic mental retardation.

References

TECR Wikipedia


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