Species Human Entrez 50839 | Human Mouse Ensembl n/a | |
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Aliases TAS2R10, T2R10, TRB2, taste 2 receptor member 10 External IDs MGI: 2681218 HomoloGene: 128355 GeneCards: TAS2R10 | ||
Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.
Function
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.
TAS2R10 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.