Entrez 4070 | Ensembl ENSG00000184292 | |
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Aliases TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, tumor-associated calcium signal transducer 2 External IDs MGI: 1861606 HomoloGene: 1763 GeneCards: TACSTD2 |
Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene.
This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor.
Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate.
References
TACSTD2 Wikipedia(Text) CC BY-SA