Synizesis (biology)

Synizesis refers to a phenomenon sometimes observed in one of the subphases of meiosis. This phenomenon, sometimes referred to as a 'synizetic knot', and contrasted with the chromosome 'bouquet' more typically observed, is characterized by the localization of the meiotic chromosomes in a tight clump on one side of the nucleus. The term synizesis seems to have been coined by McClung in 1905 [1].

The synizetic knot (Synizesis) was later found to be a technical artifact induced by the feature of strong acidic fixatives used during that time (e.g., Flemming's strong fixative) to precipitate the thread-like delicate chromosomes of the Leptotene stage of first meiotic prophase into a dark staining knot [2,3].

See also