Swimming at the 2010 Commonwealth Games – Men's 4 × 100 metre medley relay

The Men's 4 × 100 metre medley relay event at the 2010 Commonwealth Games took place on October 9, 2010, at the SPM Swimming Pool Complex.

Two heats were held, with containing nine countries. The heat in which a country competed in did not formally matter for advancement, as the countries with the top eight times from the entire field qualified for the finals.