ATC code none PubChem CID 9818479 UNII 3E93IV1U45 Molar mass 203.24 g/mol ChEMBL ID 419792 IUPHAR/BP 3949 | CAS Number 179386-43-7 IUPHAR/BPS 3949 Formula C11H13N3O Pubchem 9818479 ChemSpider ID 7994229 | |
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Sumanirole (PNU-95,666) is a highly selective D2 receptor full agonist, the first of its kind to be discovered. It was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use it is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.
In 2004, Pfizer announced the end of their clinical development program for sumanirole, citing “recent studies that failed to sufficiently distinguish sumanirole from currently available therapies”.
References
Sumanirole Wikipedia(Text) CC BY-SA