Sulfopropanediol 3-dehydrogenase (EC 188.8.131.528, DHPS 3-dehydrogenase (sulfolactate forming), 2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming), dihydroxypropanesulfonate 3-dehydrogenase, hpsN (gene)) is an enzyme with systematic name (R)-2,3-dihydroxypropane-1-sulfonate:NAD+ 3-oxidoreductase. This enzyme catalyses the following chemical reaction
(R)-2,3-dihydroxypropane-1-sulfonate + 2 NAD+
(R)-3-sulfolactate + 2 NADH + 2 H+
The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate.