Staley is a surname. Notable people with the surname include:
Dawn Staley, American basketball player and coach
Duce Staley, former professional American football player and current coach
Joan Staley, Playboy's "Miss November" 1958, movie and television actress and singer
Joe Staley, professional American football player
Jonathan Staley, English footballer
Layne Staley, lead singer of Alice in Chains and Mad Season
Luke Staley, former American, professional football player
Staley Da Bear, official mascot of the Chicago Bears
Thomas Nettleship Staley (1823–1898), first Anglican Bishop of Hawaii
Vernon Staley, Anglo-Catholic writer
Tony Staley, former Australian politician