St. Joseph's Church is in Larkana, 322 kilometres northeast of Karachi.
In 1968, Father Alex Affonso’s first assignment was as parish priest of St. Joseph's Church. Father Melito Dias was the parish priest in the 1970s, during which time he wrote regular columns about his hermitage for the Christian Voice, Karachi.
“Strong Christian families are the backbone of the Church” was the theme of an April 18, 1997 seminar organized by the Catechetical Centre, Karachi at St. Joseph's parish. Father John Mendoza was the parish priest of St. Joseph's parish at the time.
Father Kamran Taj was parish priest of St.Joseph’s Church in 2004.
Father Francis Anwar is parish priest of St. Joseph Church in Larkana, Sindh, near the ancestral home of former Prime Minister Benazir Bhutto.
Franciscan Missionaries of Mary Sisters Fauzia Rafique and Shakeela Sardar, the first parishioners from the Larkana parish of the Roman Catholic Archdiocese of Karachi to enter religious life made their final vows on April 25, 1997 at St. Lawrence's Church in a ceremony presided over by Karachi Archbishop Simeon Anthony Pereira. They become missionaries to Africa,