Spiteri is a common Maltese surname deriving from the Italian word Ospitalieri, meaning Hospitallers. It was sometimes given to illegitimate children left at the ruota during the rule of the Order of St. John. Notable people with the surname include:
Donat Spiteri, Maltese religious leader and authorGlenn Spiteri, A.R.P.S. Photographer (New York & Scotland)Mary Spiteri, Maltese cabaret artisteMatthew Spiteri, Maltese Water SkierOliver Spiteri, Maltese soccer manager and former playerRenzo Spiteri, Maltese musicianSalvino Spiteri, founder of Malta Workers' Union (UĦM)Sharleen Spiteri, singer-songwriter; guitarist; lead vocalist of the Scottish pop-rock band TexasStephen C. Spiteri, Maltese military historian