Spinola is a surname. Notable people with the surname include:
Agostino Spinola (d. 1537), Italian cardinalAlberto Spinola (born 1943), Italian water polo playerAmbrogio Spinola, 1st Marquis of the Balbases (1569–1630), Genoese banker and nobleman who served as a Spanish generalAntónio Sebastião Spínola (1875–1956), Portuguese politicianAntónio de Spínola (1910–1996), Portuguese soldier and politicianAgustín de Spínola Basadone (1597–1649), Spanish cardinal and Archbishop of SevilleBattista Spinola, 16th-century Doge of GenoaBenedict Spinola (1519/20–1580), a 16th-century Genoese merchant in LondonCharles Spinola (died 1622), Beatified Spanish Jesuit missionary martyr in JapanCristoval Rojas de Spinola (died 1695), Spanish ecclesiasticFelipe Antonio Spinola, 4th Marquis of the Balbases (1665 – after 1721), Spanish courtier and Viceroy of SicilyFilippo Spinola (1535–1593), Italian cardinalFilippo Spinola, 2nd Marquis of Los Balbases (1594–1659)Francis Barretto Spinola (1821–1891), American soldier and congressmanGiambattista Spinola (1615–1704), Cardinal and Archbishop of GenoaGiambattista Spinola, Jr (1646–1719), Italian cardinalGiandomenico Spinola (1580–1646), Italian cardinalGiovanni Battista Spinola (1681–1752), Italian cardinalMagdalena Spínola (1896-1991), Guatemalan poetMarcelo Spinola y Maestre (1835–1906), Archbishop of SavilleMaximilian Spinola (1780–1857), Italian entomologistOberto Spinola, 13th-century politician in GenoaOpicino Spinola, early fourteenth century, political leader in GenoaPaolo Spinola, 3rd Marquis of the Balbases (1628–1699), Spanish diplomatUgo Pietro Spinola (1791–1858), Italian papal diplomat and cardinal