Spinola is a surname. Notable people with the surname include:
Agostino Spinola (d. 1537), Italian cardinal
Alberto Spinola (born 1943), Italian water polo player
Ambrogio Spinola, 1st Marquis of the Balbases (1569–1630), Genoese banker and nobleman who served as a Spanish general
António Sebastião Spínola (1875–1956), Portuguese politician
António de Spínola (1910–1996), Portuguese soldier and politician
Agustín de Spínola Basadone (1597–1649), Spanish cardinal and Archbishop of Seville
Battista Spinola, 16th-century Doge of Genoa
Benedict Spinola (1519/20–1580), a 16th-century Genoese merchant in London
Charles Spinola (died 1622), Beatified Spanish Jesuit missionary martyr in Japan
Cristoval Rojas de Spinola (died 1695), Spanish ecclesiastic
Felipe Antonio Spinola, 4th Marquis of the Balbases (1665 – after 1721), Spanish courtier and Viceroy of Sicily
Filippo Spinola (1535–1593), Italian cardinal
Filippo Spinola, 2nd Marquis of Los Balbases (1594–1659)
Francis Barretto Spinola (1821–1891), American soldier and congressman
Giambattista Spinola (1615–1704), Cardinal and Archbishop of Genoa
Giambattista Spinola, Jr (1646–1719), Italian cardinal
Giandomenico Spinola (1580–1646), Italian cardinal
Giovanni Battista Spinola (1681–1752), Italian cardinal
Magdalena Spínola (1896-1991), Guatemalan poet
Marcelo Spinola y Maestre (1835–1906), Archbishop of Saville
Maximilian Spinola (1780–1857), Italian entomologist
Oberto Spinola, 13th-century politician in Genoa
Opicino Spinola, early fourteenth century, political leader in Genoa
Paolo Spinola, 3rd Marquis of the Balbases (1628–1699), Spanish diplomat
Ugo Pietro Spinola (1791–1858), Italian papal diplomat and cardinal