Spikes is the surname of:
Brandon Spikes (born 1987), American National Football League (NFL) linebackerCameron Spikes (born 1976), American former NFL football guardCharlie Spikes (born 1951), Major League Baseball playerIrving Spikes (born 1970), American former NFL running backJack Spikes (born 1937), former American collegiate and American Football League running back and placekickerJesse Spikes (born 1950), corporate lawyer who was a candidate in the 2009 Atlanta mayoral raceJohn Spikes (1881–1955), American jazz musician and entrepreneurReb Spikes (1888–1982), American jazz saxophonist and entrepreneurRichard Spikes (1884–1962), African-American engineerTakeo Spikes (born 1976), American NFL linebacker