Spikes is the surname of:
Brandon Spikes (born 1987), American National Football League (NFL) linebacker
Cameron Spikes (born 1976), American former NFL football guard
Charlie Spikes (born 1951), Major League Baseball player
Irving Spikes (born 1970), American former NFL running back
Jack Spikes (born 1937), former American collegiate and American Football League running back and placekicker
Jesse Spikes (born 1950), corporate lawyer who was a candidate in the 2009 Atlanta mayoral race
John Spikes (1881–1955), American jazz musician and entrepreneur
Reb Spikes (1888–1982), American jazz saxophonist and entrepreneur
Richard Spikes (1884–1962), African-American engineer
Takeo Spikes (born 1976), American NFL linebacker
