Spike is the nickname of:
Spike Albrecht (born 1992), American college basketball playerWilliam H. P. Blandy (1890-1954), US Navy admiralSpike Dudley (born 1970), former American professional wrestlerWilliam Eckert (1909-1971), US Air Force lieutenant general and fourth Commissioner of Major League BaseballSpike Feresten (born 1964), television writer and talk show hostSpike Jones (1911-1965), American musician and bandleaderSpike Jones (American football) (born 1947), American former National Football League punterSpike Lee (born 1957), American filmmakerSpike McRoy (born 1968), American golferSpike Milligan (1918–2002), Irish satirist, creator of the The Goon ShowWilliam W. Momyer (1916-2012), US Air Force general and World War II flying aceSpike Pola (1914–2012), Australian rules footballerSpike Robinson (1930-2001), jazz musicianSpike Spencer (born 1968), American voice actorSpike Stent (born 1965), English record producer and mixing engineerSpike, a female wrestler, one half of a tag-team with partner Chainsaw called The Heavy Metal Sisters from the Gorgeous Ladies of Wrestling