Spike is the nickname of:
Spike Albrecht (born 1992), American college basketball player
William H. P. Blandy (1890-1954), US Navy admiral
Spike Dudley (born 1970), former American professional wrestler
William Eckert (1909-1971), US Air Force lieutenant general and fourth Commissioner of Major League Baseball
Spike Feresten (born 1964), television writer and talk show host
Spike Jones (1911-1965), American musician and bandleader
Spike Jones (American football) (born 1947), American former National Football League punter
Spike Lee (born 1957), American filmmaker
Spike McRoy (born 1968), American golfer
Spike Milligan (1918–2002), Irish satirist, creator of the The Goon Show
William W. Momyer (1916-2012), US Air Force general and World War II flying ace
Spike Pola (1914–2012), Australian rules footballer
Spike Robinson (1930-2001), jazz musician
Spike Spencer (born 1968), American voice actor
Spike Stent (born 1965), English record producer and mixing engineer
Spike, a female wrestler, one half of a tag-team with partner Chainsaw called The Heavy Metal Sisters from the Gorgeous Ladies of Wrestling
