Spider is the nickname of:
Edward Dawson Atkinson (1891-?), British First World War flying ace
Woody Brown (surfer) (1912-2008), American surfer and watercraft designer
Albert Buick (1875-1948), Scottish footballer
Matthew Burton (born 1970), retired Australian rules footballer
Panagiotis Fasoulas (born 1963), Greek politician and former basketball player
Dallas Green (baseball) (born 1934), American Major League Baseball pitcher, manager and executive
Rachid Harkouk (born 1956), Anglo-Algerian former footballer
Spider Johnson (1907–1966), American football player
Billy Kelly (boxer) (1932–2010), boxer from Northern Ireland
Jim Kelly (boxer) (1912–?), boxer from Northern Ireland
Carl "Spider" Lockhart (1943–1986), American National Football League player
William L. Nyland (born 1946), retired US Marine Corps four-star general
Spider Robinson (born 1948), science fiction writer
Spider Sabich (1945-1976), American alpine ski racer
Anderson Silva (born 1975), Brazilian mixed martial arts fighter
Spider Stacy (born 1958), English musician and member of The Pogues
Darius Watts (born 1981), American former National Football League and arena football player
Travis Webb (1910-1990). American race car driver
Mark Webster (darts player) (born 1983), Welsh darts player