Symbol Spi-1 RNA type Cis-reg SO 0000204 | Rfam RF00232 Domain(s) Eukaryota | |
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The Spi-1 (PU.1) 5' UTR regulatory element is an RNA element found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5' UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.
References
Spi-1 (PU.1) 5' UTR regulatory element Wikipedia(Text) CC BY-SA