Spence is a surname. Notable persons with that surname include:
Basil Spence, British architect
Brent Spence, American Congressman, attorney, and banker
Catherine Helen Spence, Australian reformer and suffragette
Charles Spence, experimental psychologist at the University of Oxford
E. Lee Spence, author, editor, adventurer
Fiona Spence, British-Australian actress
Floyd Spence, American politician
George Spence (politician) (1880–1975), Canadian provincial and federal politician
George Spence (footballer) (born 1877), Scottish footballer
Gerry Spence, American trial lawyer
Joe Spence (footballer born 1898), English football player for Manchester United in the 1920s
Joe Spence (footballer born 1925), English football player for York City in the 1950s
John Brodie Spence, South Australian banker and politician, brother of Catherine Helen Spence
John S. Spence, American Senator from Maryland
John Selby Spence (Catholic bishop), American Catholic bishop
John Spence (politician), British Conservative MP 1970-1986
John Spence (musician), founding member of the band No Doubt
Jonathan Spence, English historian
Joseph Spence (author), English anecdotist
Joseph Spence (musician), Bahamian guitarist and blues musician
Julian Spence (1929–1990), American football player
Kenneth Spence, a prominent American psychologist
Lansford Spence, Jamaican sprinter
Lee Spence, pioneer American underwater archaeologist
Lewis Spence, journalist and writer
Louie Spence, British dancer
Michael Spence, American economist
Nicky Spence, Scottish Opera Star
Phil Spence, American basketball player and coach
Russell Spence, English race car driver
Sam Spence (born 1927), American composer/musician
Shaun Spence (born 1991), Australian Rugby League player
Skip Spence, musician
Steve Spence, American long-distance runner
Thomas Spence, Radical democrat
Toby Spence, (born 1969) English tenor
Vivienne Spence, Jamaican track and field athlete
William Spence, Australian trade union leader and politician
Wishart Spence, Justice of the Supreme Court of Canada
