Spears is a Scottish, English surname. Notable people with the surname include:
Aries Spears (born 1975), US actor and comedian
Billie Jo Spears (1937–2011), US country singer
Britney Spears (born 1981), US pop singer
Frank Sydney Spears (1906–1991), a South African artist and designer
Jamie Lynn Spears (born 1991), US actress and singer (younger sister of Britney Spears)
Lynne Spears (born 1955), mother of Britney and Jamie Lynn Spears
Ken Spears (born 1938), co-founder of Ruby-Spears Productions
Kendra Spears (born 1988), US fashion model
Major-General Sir Edward Spears, Bt, KBE (1886–1974), British army officer, MP and author
Marcus Spears (offensive tackle) (born 1971), NFL footballer
Marcus Spears (defensive end) (born 1983), NFL footballer
Rick Spears, American comics writer
Shawn Spears (born 1981), Canadian professional wrestler born Ronnie Arneill and also known as Gavin Spears
Tony Spears (born 1965), professional rugby league footballer of the 1980s
Warren Spears (1954-2005), US dancer and choreographer