Speare is a surname. Notable people with the surname include:
Elizabeth George Speare (1908–1994), American children's authorFrank Palmer Speare (1869–1954), the first president of Northeastern UniversityJamie Speare (born 1976), English footballer playing as a goalkeeperPaul Speare (born 1955), former member of Dexys Midnight Runners, The TKO Horns and The Expresso Bongo OrchestraSally Speare Lutyens (1927–2005), composer, author, and librettist