The Spartanburg and Asheville Railroad was a Southern United States railroad that served South Carolina and North Carolina in the years after the American Civil War.
The line was chartered in 1873 and in 1874 the Spartanburg and Asheville was consolidated with the Greenville and French Broad Railroad, a North Carolina line.
The line between Spartanburg, South Carolina, and Hendersonville, North Carolina, opened in 1879. It was sold under foreclosure in 1881 and reorganized under the Asheville and Spartanburg Railroad that same year.
The 21-mile distance between Hendersonville and Asheville, North Carolina, was completed in 1886. By that point, the line was operated as part of the Richmond and Danville Railroad until 1894 and controlled by the Southern Railway afterward.