Southwell is a surname. Notable people with the surname include:
Alfredo Salazar Southwell (1913–1937), aviator
Charles Southwell (1814–1860), journalist
David Southwell (born 1971), author
Dayle Southwell (born 1993), professional footballer
Hugo Southwell (born 1980), rugby player
Paul Southwell (1913–1979), Premier of Dominica and Saint Kitts-Nevis
Richard V. Southwell (1888–1970), mathematician specializing in applied mechanics
Richard Southwell (disambiguation)
Robert Southwell (disambiguation)