The Southwark by-election of 1880 was fought on 13 February 1880. The byelection was fought due to the death of the incumbent Liberal MP, John Locke. It was won by the Conservative candidate Edward George Clarke.
The 21st parliament was dissolved some weeks later and a general election was held. Beresford stood down and the seat was gained by the Liberal candidate Arthur Cohen.
References
Southwark by-election, 1880 Wikipedia(Text) CC BY-SA