Kalpana Kalpana (Editor)

Sodium proton antiporter

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Symbol
  
Na_H_antiport_1

InterPro
  
IPR004670

OPM superfamily
  
346

Pfam
  
PF06965

TCDB
  
2.A.36

OPM protein
  
1zcd

Sodium-proton antiporter

Sodium/proton antiporters are essential secondary-active transporters for sodium and pH homeostasis. In human cells, defects in sodium/proton antiport result in heart or kidney failure and other serious diseases.

Families

There are several families of sodium/proton antiporters that facilitate the exchange of sodium ions with protons across the lipid membrane. Some of them include:

  • TC# 2.A.33 - Na+:H+ Antiporter (NhaA) Family
  • TC# 2.A.34 - Na+:H+ Antiporter (NhaB) Family
  • TC# 2.A.35 - Na+:H+ Antiporter (NhaC) Family
  • TC# 2.A.36 - Monovalent Cation:Proton Antiporter-1 (CPA1) Family
  • TC# 2.A.37 - Monovalent Cation:Proton Antiporter-2 (CPA2) Family
  • TC# 2.A.62 - Na+:H+ Antiporter (NhaD) Family
  • TC# 2.A.63 - Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family
  • TC# 2.A.111 - Na+:H+ Antiporter (NhaE) Family

    • References

    Sodium-proton antiporter Wikipedia
    (Text) CC BY-SA


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