Kalpana Kalpana (Editor)

Small nucleolar RNA Z199

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Symbol
  
snoZ199

GO
  
0006396 0005730

Domain
  
Eukaryote

Rfam
  
RF00200

SO
  
0000593

Small nucleolar RNA Z199

RNA type
  
Gene; snRNA; snoRNA; CD-box

snoRNA Z199 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA Z199 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

snoZ199 is predicted to be a methylation guide for sites on 18S and 25S ribosomal RNA (rRNA). Oryza sativa snoZ199 is reported to be homologous to Arabidopsis thaliana snoR13.

References

Small nucleolar RNA Z199 Wikipedia