Girish Mahajan (Editor)

Small nucleolar RNA SNORD44

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Symbol  SNORD44
Rfam  RF00287
SO  0000593
Alt. Symbols  U44
GO  0006396 0005730
Domain  Eukaryote
Small nucleolar RNA SNORD44 httpsuploadwikimediaorgwikipediacommonsthu
RNA type  Gene; snRNA; snoRNA; C/D-box

snoRNA U44 (also known as SNORD44) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U44 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

U44 was originally cloned from HeLa cells and expression verified by northern blotting. It is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA(rRNA) at residue A166. In the human genome, U44 is located in the same gene as several other C/D box snoRNAs (U47, U74, U75, U76, U77, U78, U79, U80 and U81).


Small nucleolar RNA SNORD44 Wikipedia