Girish Mahajan (Editor)

Small nucleolar RNA SNORD44

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Symbol
  
SNORD44

Rfam
  
RF00287

SO
  
0000593

Alt. Symbols
  
U44

GO
  
0006396 0005730

Domain
  
Eukaryote

Small nucleolar RNA SNORD44 httpsuploadwikimediaorgwikipediacommonsthu

RNA type
  
Gene; snRNA; snoRNA; C/D-box

snoRNA U44 (also known as SNORD44) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoRNA U44 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.

U44 was originally cloned from HeLa cells and expression verified by northern blotting. It is predicted to guide 2'O-ribose methylation of 18S ribosomal RNA(rRNA) at residue A166. In the human genome, U44 is located in the same gene as several other C/D box snoRNAs (U47, U74, U75, U76, U77, U78, U79, U80 and U81).

References

Small nucleolar RNA SNORD44 Wikipedia