Supriya Ghosh (Editor)

Small Cajal body specific RNA 21

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Symbol
  
SCARNA21

Domain(s)
  
Eukaryota

Rfam
  
RF00602

SO
  
0000275

Small Cajal body specific RNA 21

RNA type
  
Gene; snRNA; snoRNA; scaRNA

GO
  
0006396 0015030 0005730

In molecular biology, Small Cajal body specific RNA 21 (also known as scaRNA21 or ACA68) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U12 minor spliceosomal RNA.

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.

ACA68 (SCARNA21) is a member of the H/ACA box class of snoRNAs that guide the sites of modification of uridines to pseudouridines. This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis. ACA68 is proposed to guide the pseudouridylation of residue U19 in U12 snRNA.

References

Small Cajal body specific RNA 21 Wikipedia