Sly or Slye is the surname of:
People:
Darryl Sly (1939-2007), Canadian National Hockey League player
Damon Slye (born 1962), computer game designer, director and programmer
Harold Sly (1904-?), English professional association football player
James Calvin Sly (1807-1864), Mormon pioneer, scout, settler and missionary
Leonard Slye, birth name of Roy Rogers (1911-1998), America singer and actor
Maud Slye (1879-1954), American pathologist
Tony Sly (born 1970), American singer, songwriter and guitarist, best known as the frontman of the punk rock band No Use for a Name
William Sly (died 1608), Elizabethan actor and colleague of William Shakespeare
Fictional characters:
Christopher Sly, in Shakespeare's play The Taming of the Shrew