Sisulu is a surname. People with this surname include:
Albertina Sisulu (1918–2011), anti–apartheid activistLindiwe Sisulu (born 1954), South African Minister of Defence and Military VeteransMax Sisulu, Speaker of the National Assembly of South AfricaSamuel Sisulu (1956 - 2003), South African anti-apartheid activist, Soweto uprising student leader and founder of South African Freedom Organisation (SAFO)Walter Sisulu (1912–2003), Secretary-General of the African National CongressZwelakhe Sisulu (1950-2012), South African journalist, editor, newspaper founder, CEO of SABC, and businessperson