Signorelli is a surname. Notable people with the surname include:
Angelo Signorelli (1876–1953), Italian Physician
Franco Signorelli (born 1991), Venezuelan footballer
Frank Signorelli (1901–1975), American jazz pianist
James Signorelli, American film director and cinematographer
Luca Signorelli (c. 1445 – 1523), Italian Renaissance painter
Vincent Signorelli, American punk rock drummer