Shifrin (Yiddish: שיפרין, Russian: Шифрин ) is a matronymic Jewish surname of Yiddish origin. Notable people with the surname include:
David Shifrin, American classical clarinetist
Eduard Shifrin, Ukraine born billionaire
Efim Shifrin, Russian actor and comedian
Eleonora Shifrin, Soviet Union born Israeli politician
Karin Shifrin, Israeli opera singer
Lalo Schifrin, Argentine pianist and composer
Richard Shiffrin, American professor
Seana Shiffrin, American professor
Seymour Shifrin, American composer
Mikaela Shiffrin, American alpine skier
Dr. Gregory Shifrin, MD, Obstetrician-Gynecologist in New York
Mitchell Shifrin, Founder of A A Affordable Insurance Agency of Ohio