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The Royal Infirmary was a hospital in Sheffield, South Yorkshire. The establishment opened in 1792 under the name Sheffield General Infirmary, renamed Royal Infirmary in 1897 and closed in the 1980s.
Built by J.D.Webster & Sons, many of the establishment's features made it unique. An innovative octagonal outpatients department was built in 1884, and was lit by a cupola. It had a roof of wrought iron lattice girders and a tiled waiting room with the consulting rooms leading off it. Young & Hall, specialists in hospital architecture, extended it in 1900. A nurses' home with the name "Centenary House" was built on the grounds in 1897.
The original block, along with its south-east and south-west wings, has been renamed Heritage House and is a Grade II* listed building. Part of the site is now occupied by a Tesco supermarket and part is offices occupied by [Aviva] insurance.
The hospital was used for filming a casualty scene from an imagined nuclear attack on Sheffield in the 1984 film Threads.