Sheen is a surname. Notable people with the surname include:
Barry Sheen (1918–2005), British judge
Billy Sheen (born 1989), English rugby league footballer
Bobby Sheen (1941–2000), American singer
Brian Sheen (born 1952), American complementary and alternative medicine practitioner
Caroline Sheen (born 1975), Welsh actress
Charlie Sheen (born 1965), American actor
Danielle Sheen (born 1990), English footballer
Edna Sheen (1944–2012), American make-up artist
Everett Sheen (born 1986), Canadian ice hockey player
Fulton J. Sheen (1895–1979), Catholic archbishop, television evangelist, sainthood candidate
Gillian Sheen (born 1928), British fencer (won Olympic gold)
Graham Sheen (born 1952), British bassoonist
Grant Sheen (born 1974), English cricketer
Jacqueline Sheen (born 1963), model
Martin Sheen (born 1940), American actor
Michael Sheen (born 1969), Welsh actor
Mickey Sheen (1927–1987), American jazz drummer
Ruth Sheen (born 1952), English actress
Fictional characters:
Emma Sheen, a character in the anime series Mobile Suit Zeta Gundam
