Sfondrati is an Italian surname. Notable people with the surname include:
Francesco Sfondrati (1493–1550), Italian Roman Catholic bishop and cardinal and the father of Pope Gregory XIV
Niccolo Sfondrati (11 February 1535 – 16 October 1591), Pope known as Pope Gregory XIV
Paolo Emilio Sfondrati (1560 – 14 February 1618), Italian Cardinal
Celestino Sfondrati (10 January 1644 – 4 September 1696), Italian Benedictine theologian, Prince-abbot of St. Gall and Cardinal