Seyfried is a surname. Notable persons with that surname include:
Amanda Seyfried (born 1985), American actress
David Seyfried Herbert, 19th Baron Herbert (born 1952), British peer
Gordon Seyfried (born 1937), Major League Baseball pitcher
Ignaz von Seyfried (1776–1841), Austrian musician, conductor and composer
Vincent F. Seyfried (1918–2012), American historian