The gens Sertoria was a Roman family, probably of Sabine origin. It was relatively undistinguished, except for the Roman general Quintus Sertorius (123-72 BC), who fought alongside Gaius Marius and Lucius Cornelius Cinna, and later established an independent state in Hispania during the dictatorship of Lucius Cornelius Sulla.
Sertorius was born at Nursia, where his family had lived for several generations. The name of the gens is a patronymic surname, based on the praenomen Sertor, which was considered archaic at Rome by the 1st century BC It may have meant, one who protects or preserves. Although Quintus was a very common name, the Sertorii were accustomed to choosing rare and archaic praenomina, such as Proculus.
Sertorius was murdered by Marcus Perperna, leaving no issue. Afterward, the Sertorii once again faded into obscurity.