Species Human Entrez 51593 | Human Mouse Ensembl ENSG00000087087 | |
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Aliases SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule External IDs MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT | ||
Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.
The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding the SOX2 promoter and positively regulating its transcription.
It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis.
References
Serrate RNA effector molecule homolog Wikipedia(Text) CC BY-SA