Species Human Entrez 5552 | Human Mouse Ensembl ENSG00000122862 | |
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Aliases SRGN, PPG, PRG, PRG1, serglycin External IDs HomoloGene: 2043 GeneCards: SRGN | ||
Serglycin, also known as hematopoetic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells.
Function
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.
References
Serglycin Wikipedia(Text) CC BY-SA