Semler is a surname. Notable people with the surname include:
Borut Semler (born 1985), Slovene footballer
Dean Semler (born 1943), Australian cinematographer
Gustav Adolf Semler (1885–1968), German film actor of the silent era
Johann Salomo Semler (1725–1791), German church historian and Biblical commentator
Ricardo Semler (born 1959), the CEO and majority owner of the Brazilian company of Semco SA