Semedo is a Portuguese surname, it may refer to:
Álvaro Semedo (1586–1658 or 1659), Portuguese Jesuit, Vice-Provincial of Jesuit China Mission in south China during the Ming/Qing changeover
Gil Semedo, Cape Verdean singer
Cafú (footballer, born 1977), real name Arlindo Gomes Semedo, Cape Verdean football forward
Nélson Cabral Semedo, Portuguese football right-back
José Filipe Correia Semedo, Cape Verdean football forward
Cícero Semedo, Guinea-Bissauan football forward
António Semedo, former Portuguese football forward
José Orlando Semedo, former Portuguese football midfielder
José Vítor Moreira Semedo, Portuguese football defender
Curvo Semedo, Portuguese poet
