Seiler is a surname. Notable people with the surname include:
Jack Seiler (born 1963), American politician and Mayor of Fort Lauderdale, FloridaKerim Seiler (born 1974), Swiss artist and architectLewis Seiler (1890–1964), American film directorPaul Seiler (1945–2001), American football playerReinhard Seiler (1909–1989), German Luftwaffe pilotRobert Eldridge Seiler (born 1912), American judge on the Missouri Supreme CourtSebastian Seiler (1810–1890), German journalistSonny Seiler (born 1933), American attorney and bulldog ownerBruce Seiler (born 1956), American Automotive Parts & Service LeaderAlexander Seiler (born 1995) 2K World ChampionPreston Seiler (born 1998) Actual NBA 2K World ChampionAlexandre J. Seiler (born 1918), Swiss director