Seiler is a surname. Notable people with the surname include:
Jack Seiler (born 1963), American politician and Mayor of Fort Lauderdale, Florida
Kerim Seiler (born 1974), Swiss artist and architect
Lewis Seiler (1890–1964), American film director
Paul Seiler (1945–2001), American football player
Reinhard Seiler (1909–1989), German Luftwaffe pilot
Robert Eldridge Seiler (born 1912), American judge on the Missouri Supreme Court
Sebastian Seiler (1810–1890), German journalist
Sonny Seiler (born 1933), American attorney and bulldog owner
Bruce Seiler (born 1956), American Automotive Parts & Service Leader
Alexander Seiler (born 1995) 2K World Champion
Preston Seiler (born 1998) Actual NBA 2K World Champion
Alexandre J. Seiler (born 1918), Swiss director